Table 1.
Baseline Demographics of Patient Groups
|
ICU Sepsis |
ICU Controls |
Healthy Controls |
ANOVA P-value |
|
| Number of Subjects | 24 | 25 | 21 | |
| Age, mean (SD) | 54.0 (17.1) | 56.1 (15.9) | 46.5 (6.1) | 0.13 |
| Male Gender, n (%) | 15 (58) | 13 (52) | 17 (80) | 0.49 |
| Black or African American race, n (%) |
22 (92)† | 14 (56) | 15 (71) | 0.02 |
| White race, n (%) | 2 (8) | 11 (44) | 5 (29) | 0.02 |
| HIV infected, n (%) | 4 (17) | 0 | 0 | 0.02 |
| Diabetes, n (%) | 9 (38) | 6 (24) | 2 (10) | 0.09 |
| Cardiovascular disease, n (%) | 14 (58) | 17 (68) | 8 (38) | 0.12 |
| Malignancy, n (%) | 2 (8) | 0 | 1 (5) | 0.35 |
| APACHE Score, mean (SD) |
25.7 (7.4) | 11.8 (5.4) | N/A | <0.0001 |
| SOFA, mean (SD) | 11.9 (4.0) | 5.3 (3.2) | N/A | <0.0001 |
| Albumin, mean (SD) mg/dL | 2.0 (2.6)‡ | 2.1 (0.7)# | 4.0 (0.5) | <0.0001 |
| Prothrombin Time (PT) mean (SD)* |
16.7 (2.9) | 15.3 (2.8) | 16.8 (3.9) | 0.98 |
| Partial thromboplastin time (PTT) mean (SD)* |
48.8 (37.0) | 35.1 (5.3) | 34.8 (1.7) | 0.05 |
| INR, mean (SD) | 1.6 (0.4)†‡ | 1.2 (0.3) | 1.3 (0.4) | 0.0009 |
| AST, mean (SD), units/L |
87.0 (131) | 49.9 (48) | 33.0 (26) | 0.09 |
| ALT, mean (SD), units/L |
43.6 (44) | 51.3 (75) | 25.4 (17) | 0.24 |
| BUN, mean (SD), mg/dL |
52.4 (28) †‡ | 27.8 (17)# | 12.6 (5.1) | <0.0001 |
| Creatinine, mean (SD), mg/dL |
4.0 (3.2) †‡ | 1.1 (0.7) | 1.0 (1.1) | <0.0001 |
| Hemoglobin, mean (SD) g/dL |
9.8 (2.0)‡ | 10.6 (1.2)# | 13.8 (1.1) | <0.0001 |
| White Blood Count (cells/μL) |
17.3 (13)‡ | 15.2 (7.1)# | 6.5 (1.9) | <0.0002 |
* in seconds
Tukey-Kramer Multiple Comparisons Test
† P < 0.05, ICU Sepsis vs ICU Controls
‡ P < 0.05, ICU Sepsis vs Healthy Controls
# P < 0.05, ICU Control vs Healthy Controls