Table 3.

Odds ratios and CACS estimates according to number, sex, type, lineage and age at onset of relatives with CHD, stroke or diabetes in MESA subjects at baseline

Family History Variables	n	Odds ratioa CAC>0 (95% CI)	Mean Adjusted CACS Estimateb (95% CI)
Youngest age at onset
No affected relative	2,962	1.0	106 (94, 117)
Age <40	108	2.7 (1.7, 4.2)g	220 (125, 315)
Age 40 to 60	881	1.7 (1.4, 2.0)g	173 (144, 203)
Age >60	1,287	1.6 (1.4, 1.9)g	160 (138, 182)
Number of affected relatives
No affected relative	2,962	1.0	105 (94, 117)
1	1,589	1.6 (1.4, 1.8)g	148 (128, 167)
2	506	1.8 (1.5, 2.3)g	193 (152, 233)
3+	207	2.4 (1.7, 3.4)g	244 (172, 316)
Sex of affected relative
No affected relative	2,962	1.0	106 (95, 118)
Male	1,241	1.5 (1.3, 1.8)g	154 (131, 176)
Female	603	1.8 (1.5, 2.2)g	155 (125, 185)
Male and Female	458	2.0 (1.5, 2.5)g	222 (173, 270)
Type of affected relative
No affected relative	2,962	1.0	106 (94, 117)
Parents and no siblingsc	1,306	1.6 (1.4, 1.9)g	156 (133, 180)
Siblings and no parentsc,d	580	1.6 (1.3, 2.0)h	158 (128, 187)
Parents and siblingsc	416	2.1 (1.6, 2.7)g	206 (160, 251)
Lineage of affected relative
No affected relative	2,962	1.0	106 (95, 118)
Maternale	560	1.8 (1.4, 2.2)g	169 (134, 204)
Paternale	956	1.7 (1.4, 2.0)g	155 (130, 181)
Maternal and paternale	206	1.6 (1.2, 2.3)h	264 (174, 353)
Nuclearf	580	1.6 (1.3, 2.0)g	157 (127, 187)

CACS, coronary artery calcification score; CHD, coronary heart disease; CI, confidence interval

For each analysis, all p-values were adjusted for five comparisons (i.e., the models considering the five different family history variables of youngest age at onset, number of relatives affected, sex of affected relatives, type of affected relatives and lineage of affected relatives) using the Bonferoni method with a significance threshold value of 0.01.

^aAdjusted for age, sex, education, income, marital status, study site, family size, current smoking status, LDL cholesterol, HDL cholesterol, triglycerides, systolic blood pressure, diastolic blood pressure and body mass index

^bMean CACS estimate is the mean value calculated by pooling the results from the logistic and the log-transformed linear models

^cCan include children

^dIncludes 48 subjects with only children affected with CHD

^eCan include siblings and children with CHD

^fIncludes siblings and/or children with CHD but no affected parents

^gP-value <0.01, statistically significant after adjustment for five multiple comparisons using the Bonferoni method

^hP-value =0.01, at the threshold of statistical significance after adjustment for five comparisons using the Bonferoni method