Table 1.

Baseline Characteristics of the Subjects

Variable	Placebo Group (N=169)	B Vitamins Group (N=240)	All Subjects (N=409)
Age – yr	77.3±7.9	75.7±8.0	76.3±8.0
Female sex – no. (%)	91 (53.9)	138 (57.5)	229 (56.0)
Education – yr	13.9±3.2	14.0±2.9	13.9±3.1
APOE ε4 carrier – no. (%)	105 (70.0)	141 (64.7)	246 (66.9)
MTHFR genotype – no. (%)
CC	54(40.6)	80(41.5)	134(41.1)
CT	56(42.1)	86(44.6)	142(43.6)
TT	23(17.3)	27(14.0)	50(15.3)
Homocysteine level	9.10±2.8	9.20±3.4	9.16±3.2
Folate level	23.59±14.35	25.74±17.65	24.85±16.38
Vitamin B12 level	577.46±281.08	605.68±304.10	593.99±294.76
Vitamin B6 level*	6.55(5, 81.85)	5.00(5, 67.65)	5.00(5, 71.95)
Smoker – no. (%)	49 (29.0)	79 (32.9)	128 (31.3)
ADAS-Cog score	22.63±8.6	22.43±9.0	22.51±8.8
MMSE score	20.91±3.7	20.98±3.4	20.95±3.5
CDR sum-of-boxes score	5.85±2.9	5.61±2.7	5.71±2.8
Score on Neuropsychiatric Inventory*	5.00(1, 11)	6.00(0, 13)	6.00(0, 12)
Score on Activities of Daily Living Scale	59.66±12.9	61.31±11.58	60.63±12.15

^*Note: Median(Q1,Q3)