Table 2.
Changes from Baseline in Cognitive and Functional Measures
| Test | Change in Score from Baseline | |||||
|---|---|---|---|---|---|---|
| 3 mo | 6mo | 9mo | 12mo | 15mo | 18mo | |
| Cognitive and functional measures | ||||||
| ADAS-Cog | ||||||
| Placebo | 1.51±4.68 | 1.72±4.74 | 2.71±6.63 | 4.46±6.32 | 5.80±6.34 | 6.54±8.17 |
| B Vitamins | 1.58±5.61 | 2.44±6.04 | 2.97±6.57 | 4.42±6.61 | 6.31±7.71 | 7.38±9.72 |
| MMSE | ||||||
| Placebo | −0.67±2.89 | −1.13±3.13 | −1.70±3.83 | −1.80±3.56 | −2.51±3.59 | −3.08±4.46 |
| B Vitamins | −0.17±3.02 | −0.44±3.19 | −0.89±3.26 | −1.64±3.84 | −2.15±4.21 | −2.65±4.56 |
| CDR sum of boxes | ||||||
| Placebo | - | 0.79±1.65 | - | 1.60±2.12 | - | 2.51±2.57 |
| B Vitamins | - | 0.69±1.67 | - | 1.50±1.92 | - | 2.58±2.45 |
| Neuropsychiatric Inventory | ||||||
| Placebo | 0.64±4.83 | 1.03±8.82 | 0.76±8.90 | 1.19±9.31 | 3.83±13.74 | 2.20±11.12 |
| B Vitamins | 0.71±6.31 | 0.97±10.82 | 0.12±11.27 | 1.03±10.53 | 2.97±11.20 | 3.31±12.84 |
| Activities of Daily Living Scale | ||||||
| Placebo | - | −2.86±7.80 | - | −7.82±10.00 | - | −10.00±11.09 |
| B Vitamins | - | −3.28±7.99 | - | −7.38±9.97 | - | −10.96±12.36 |
Note: ADAS total score rage: 0–70, 70 being the most impaired; MMSE total score range: 0–30, 30 being the least impaired; CDR sum of boxes range: 0–18, 18 being the most impaired; Neuropsychiatric Inventory range: 0–144, 144 being the most impaired; Activities of Daily Living Scale range: 0–78, 78 being the most impaired.