Figure 1.

Statistical parametric maps of the signal change to novel versus previously learned items, and the reverse, in the negative family history (−FH) group (top) (n = 64), and the positive family history (+FH) (middle) group (n = 68) collapsed across APOE status. The bottom row contains the results of the SPM{t} contrast of the difference (Diff) between FH groups indicating greater activity in the mesial and ventral temporal lobe in the −FH group (there were no significant voxels in the reverse direction). The statistical maps are overlaid on the same atlas brain in Montreal Neurological Institute (MNI) space. All maps are constrained to voxels in which the global F statistic was significant (p_FWE < 0.05). Left is on the left of the image. The single-group contrasts (top two rows are thresholded at p_FWE < 0.05; t = 4.11); the between-group contrast (on which inferences are based) is thresholded at p_FDR < 0.005; t = 3.10. The positive (hot colors) and negative (blue) t-maps are shown for the single-group maps. See Table 2 for a summary of the statistical results and voxel coordinates of maxima. L, Left; R, right.