Table 2.
Rank | Transcripts | Gene bank ID | Location of conserved `zipcode' sequences | Scald fold enrichment MTLn3-ZBP1/MTLn3 | Biological functions |
---|---|---|---|---|---|
A1 | β-actin | NP_112406 | 3′ UTR | 223.1 | Cytoskeleton; cell motility |
A2 | P21-ARC (subunit 3) | NM_001105933 | Coding region | 215.0 | Actin cytoskeleton regulation |
A3 | Galectin-3 | NP_114020 | Absent | 194.6 | Heterophilic cell adhesion |
A4 | Endolyn | NM_031812 | Coding region | 83.9 | Cell adhesion; cell proliferation |
A5 | P16-ARC (subunit 5) | NM_001037767 | Absent | 60.5 | Actin cytoskeleton regulation |
A6 | Evl (RNB6) | NM_024147 | Coding region | 42.2 | Actin-filament-based movement; cell motility |
A7 | Actinin α1 | NP_112267 | Coding region | 33.6 | Actin cross-linking; actin organization |
A8 | E-cadherin | NP_112624 | 3′ UTR | 33.1 | Cell adhesion |
A9 | β-catenin | NP_445809 | Coding region | 26.5 | Cell-cell contacts; Wnt signaling |
B1 | Cyclin D1 | NP_741989 | Coding region | 241.4 | Cell proliferation; Wnt signaling |
B2 | Hepatoma-derived growth factor | NP_446159 | 3′ UTR | 60 | Cell proliferation |
B3 | Cyclin A2 | NM_053702 | Absent | 28.7 | Cell proliferation |
B4 | Anxa1 | NP_037036 | Absent | 48.4 | Regulation of cell proliferation |
B5 | Erv1, growth factor homolog | NP_037354 | Coding region | 32.7 | Cell proliferation |
B6 | Rcl | NP_598209 | Absent | 21.9 | Cell proliferation; putative Myc-responsive |
B7 | Cyclin G1 | NP_037055 | Coding region | 21.8 | Cytokinesis; mitosis; cell-cycle regulation |
B8 | Frk (Src-related tyrosine kinase) | NM_024368 | Coding region | 19.4 | Cell differentiation |
Microarray experiments and data analyses were performed in the Center for Functional Genomics at the University of Albany. Two categories of 17 transcripts were selected from the microarray results. One category of mRNAs contained transcripts important for cell motility and adhesion (rank A1-A9). The second category of ZBP1-bound mRNAs included those necessary for cell mitosis and growth (rank B1-B8). Location of the conserved `zipcode' sequences within the transcripts is indicated.