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. Author manuscript; available in PMC: 2009 May 20.
Published in final edited form as: J Neurosci Methods. 2007 Sep 12;168(1):15–25. doi: 10.1016/j.jneumeth.2007.09.002

Figure 4. Effect of lovastatin (A, B) or CP-340868 (C, D) on lipid syntheses in the WT mice brains.

Figure 4

Mice at PND 8 were peritoneally injected with 10 μg of Lovastatin/g of body weight, or were subcutaneously injected with 10 μg of CP-340868 (SSI)/g of body weight. The control mice were injected with the same amount of vehicle only. The injections were given once every day for 8 days. On day 15, 3 μl of 3H-acetate (100 μCi) per mouse was injected into the lateral ventricle of the brains; 1 hr later mice were sacrificed and the brains were processed for lipid analyses according to procedures described in the Materials and Methods section. The results shown are representative of three separate experiments. For each experiment, 9 mice were used for each group. Lovastatin was prepared at 1 mg/ml of lovastatin in mazol PG810 (propylene glycol dicaprylate). SSI was prepared at 1 mg/ml of saline. Each bar represents the mean + SEM. For sterol synthesis values, statistical analysis showed that the difference in values between the SSI-treated or the lovastatin-treated group and the control group was significant. For fatty acid synthesis values, statistical analysis showed that there was no significant difference in values between the SSI-treated or the lovastatin-treated group and the control group.