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. 2009 Mar 16;75(6):1400–1411. doi: 10.1124/mol.108.054510

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Copyright © 2009, The American Society for Pharmacology and Experimental Therapeutics

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Fig. 8. — The presence of the α1Q241W mutation affects channel activation by P4S. A, sample single-channel currents from the γβα-βα receptor exposed to 1 mM P4S. No clusters were evident. A portion of the current trace is shown at higher resolution in the bottom trace. B, sample single-channel currents from the γβαQ241W-βα receptor exposed to 1 mM P4S. One cluster is shown. A portion of the cluster is shown at higher resolution in the bottom trace. C, sample single-channel currents from the γβα-βαQ241W receptor exposed to 1 mM P4S. One cluster is shown. A portion of the cluster is shown at higher resolution in the bottom trace. D, sample single-channel currents from the γβαQ241W-βαQ241W receptor exposed to 1 mM P4S. One cluster is shown. A portion of the cluster is shown at higher resolution in the bottom trace.