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Mutation-induced changes in the affinities of the antagonist NMS (a) and novel selective agonists NDMC (b), AC-42 (c), and 77-LH-28-1 (d). The histogram represents variations of log-affinity constant ΔpKd ± S.E.M. for each mutant, compared with the wild-type, calculated from Table 1. NC designates noncompetitive behavior, defined by a value of the cooperativity factor α ≥0.01 (see Materials and Methods). *, P < 0.05; **, P < 0.01; ***, P < 0.001 with respect to wild type.
