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. 2008 Dec 19;75(3):514–524. doi: 10.1124/mol.108.048744

Fig. 4.

Fig. 4.

T62D mutation confers DA leak. Representative amperometric current obtained from hDAT (A), T62A-hDAT (B), and T62D-hDAT (C). Cells were preloaded by incubating them in a bath solution containing 1 μM DA. Cells were then washed, and DA leak was estimated by measuring the decrease in amperometric current upon cocaine application. D, DA leak from hDAT (n = 8), T62A-hDAT (n = 7), and T62D-hDAT (n = 12) cells reported as mean ± S.E.M. The dotted horizontal lines represent the amperometric currents recorded when all dopamine transporters are blocked by cocaine. *, one-way ANOVA, p < 0.001; in Bonferroni post tests, p < 0.01 for T62D-hDAT versus T62A-hDAT and hDAT.