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. 2009 Jun 5;5(6):e1000464. doi: 10.1371/journal.ppat.1000464

Figure 5. Parameters of acute lung injury in Wt and TLR4 mut mice.

Figure 5

(A) Lung injury (as measured by leak of 125I-BSA into lung) in Wt, TLR4 mut, TLR4+/+, and TLR4−/− mice receiving LPS intratracheally. (B) Permeability indices in Wt, TLR4 mut, TLR4+/+, and TLR4−/− mice after intrapulmonary immune complex formation following administration of BSA (i.v.) and anti-BSA IgG (i.t.). (C) IL-6 levels in BAL fluids after IgG immune complex (IgGIC)- or LPS-induced lung injury using Wt and TLR4 mut mice. (D) TNFα in BAL fluids from the same mice described in frame (C). For each bar, n≥5. (E) Lung injury induced by IgG immune complexes (IgGIC) in Wt and TLR4 mut mice after endotoxin removal by polymyxin. (F) Lung permeability after intratracheal (i.t.) administration of anti-BSA IgG and intravenous (i.v.) injection of BSA, PBS i.t., and BSA i.v. or anti-BSA i.t. and PBS i.v. (G) IgGIC-induced lung injury in FcRγ-subunit−/− mice in comparison to Wt mice (FcRγ-subunit+/+). For each bar, n≥5.