Table 3. Risk of lung cancer-specific death in proband's relative (child, sibling, spouse) depending on proband survival.
Pairs of relatives | Survival in probanda | Number of relatives to proband | Number of deaths in relative to proband | Risk of lung cancer related death in proband's relative | |||
Adjusteda | Trend test | Adjustedc | Trend test | ||||
HR (95% CI) | p valuesb | HR (95% CI) | p valuesb | ||||
Parentd-Childe | 0.05 | 0.04 | |||||
Good | 109 | 67 | 0.73 (0.52–1.00) | 0.71 (0.51–0.99) | |||
Expected | 221 | 157 | 0.87 (0.68–1.16) | 0.86 (0.65–1.13) | |||
Poor | 109 | 83 | 1.0 ref. | 1.0 ref. | |||
Sibling-Siblinge | 0.02 | 0.05 | |||||
Good | 15 | 4 | 0.24 (0.072–0.81) | 0.14 (0.030–0.65) | |||
Expected | 32 | 25 | 1.42 (0.66–3.05) | 1.26 (0.48–3.27) | |||
Poor | 16 | 10 | 1.0 ref. | 1.0 ref. | |||
Spouse-Spoused | 0.32 | 0.26 | |||||
Good | 131 | 97 | 0.87 (0.66–1.15) | 0.85 (0.64–1.13) | |||
Expected | 262 | 196 | 0.91 (0.71–1.15) | 0.90 (0.70–1.15) | |||
Poor | 132 | 102 | 1.0 ref. | 1.0 ref. |
Multivariate proportional hazard (Cox) model adjusted for calendar year of diagnosis and age at diagnosis.
One degree of freedom.
Multivariate proportional hazard (Cox) model adjusted for calendar year, age and place of diagnosis, socioeconomic status, tumour histology and gender.
Parents (Spouses) diagnosed between January 1961 and December 2001.
Children (siblings) diagnosed between January 1991 and December 2001.