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. 2008 Sep 29;75(1):134–142. doi: 10.1124/mol.108.050567

Fig. 2.

Fig. 2.

Compound synthesis and structure-activity analysis. A, structures of CNTinh-03 and CNTinh-04. B, synthesis of CNTinh-03. Reagents and conditions: (a) AcOH, NH4OAc, C6H6 (azeotropic); (b) sulfur, Et2NH, dry THF-MeOH, 35-40°C; (c) melt reaction. C, summary of structure-activity data obtained from screening of 124 analogs (see text for explanations). D, inhibition of short-circuit current (left) and cAMP (right) by CNTinh-03 in FRT-V2R cells after addition of 1 nM dDAVP. Cells were incubated with dDAVP and indicated concentrations of CNTinh-03 for 20 min before cAMP assay. Data shown as mean ± S.E. (n = 3).