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Inhibition by PTA2 of U46619's activation of Gq and G13 in platelet membranes. Membranes from human platelets were incubated with 1 μM U46619, the indicated concentrations of PTA2, and [35S]GTPγS. Binding of [35S]GTPγStoGαq and Gα13 was evaluated as described in the legend to Fig. 2. The data are from single experiments performed in duplicate, which are representative of two others each for Gq and G13, and are expressed as counts per minute.
