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. 2009 Apr 1;37(9):3110–3123. doi: 10.1093/nar/gkp136

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — A model for the regulation of ERα transcriptional activity, involving CK1δ and AIB1. In the presence of E2, CK1δ interacts with and phosphorylates AIB1 predominantly at S601 and probably ERα at other site(s), inducing the formation of a complex between them that is required for the complete transcriptional activity of ERα. Inhibition of CK1δ-mediated phosphorylation, potentially alters the conformation of AIB1 and promotes its proteasome-mediated degradation; subsequently, ERα protein levels are stabilized and ERα activity is decreased.