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Sequence of the nuclease hypersensitive element (NHE) in the human KRAS promoter. The G-rich sequence 32R forms a G-quadruplex whose putative structure, consistent with CD and dimethyl sulfate footprinting, is G4-DNA1, which is characterized either by a flipped-out thymidine connecting G7 to G9 or a GGGT triad (13). The expected G4-DNA2 structure is not supported by dimethyl sulfate footprinting. The nucleotides of 32R (Table 1) are numbered from the 5′-end.
