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Overview of signaling upstream of ASK1 and ASK2. Various stimuli activate ASK1 and ASK2. In some of these stimuli, ROS generation is required to activate the ASK family. The recruitment of TRAF2 and/or TRAF6 to ASK1 is also important in the activation. ASK1 and ASK2 can form a complex in the cell. For details, see text.
