Figure 4.

Systemic passive immunization prevents the disruption of synaptic plasticity by Aβ dimer-containing huCSF in vivo. Animals received an intracardiac injection of the monoclonal anti-Aβ antibody 4G8 (0.15–0.2 mg/rat), 30 min before an intracerebroventricular injection of either untreated (n = 5) or immunodepleted (n = 5) huCSF (10 μl; asterisk) and 40 min before high-frequency stimulation (arrow). Insets and calibration are as in Figure 1. Error bars indicate SEM.