Fig. 5.
PICK1 and KRIP6 compete for functional regulation of recombinant GluR6. (A) Families of whole-cell currents evoked by 300 µM kainate in COS-7 cells transfected with CFP (47 cells), mRFP-PICK1 (26 cells), mRFP-PICK1 + CFP-KRIP6 (15 cells) or CFPKRIP6 (34). Curves superimposed in color show the average of currents evoked in all cells tested. (B) Peak current, steady-state/peak current, and decay time constant (Tau) are plotted as a percent of the mean values obtained with CFP alone. *Different from CFP alone (p < 0.05, t-test); #different from mRFP-PICK1 alone and from CFP-KRIP6 alone (p < 0.05, t-test), but not different from CFP alone (p > 0.05, t-test).