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Effect of HS and NS on disease activity index (DAI) in mice with DSS-induced colitis. Clinical activity in DSS colitis was improved by treatment with 4 ml/kg (HS4, n = 6) and 8 ml/kg hypertonic saline (HS8, n = 10) but also by fluid replacement therapy with 8 ml/kg normal saline (NS8, n = 10), compared with DSS mice without further treatment (DSS, n = 12). Statistical analysis was done by ANOVA. *P < 0.05 and **P < 0.01 compared with DSS alone. Values are means ± SE.
