Table 3.

Recovery sleep (% change from baseline)

	Wt	db/db	P
NREM
4-h Light	+15±2.7	+15.1±3.0
12-h Dark	+34±7.0	+13.6±3.4	*
16-h Total	+25±3.8	+13.6±2.3	*
REM
4-h Light	+25±9.0	+3.5±7.8	*
12-h Dark	+159±29.6	+62.0±10.2	†
16-h Total	+79±9.4	+38.0±6.9	†
TST
4-h Light	+15.3±2.4	+15.3±2.4
12-h Dark	+40.4±6.9	+16.4±3.3	†
16-h Total	+29.3±3.5	+15.2±2.3	†
NDP
4-h Light	+44.5±5.2	+34.3±3.1
12-h Dark	−13.1±2.6	−11.9±1.9
16-h Total	+5.4±2.7	+1.7±1.6

The magnitude of recovery sleep following acute (i.e., 6-h) sleep deprivation was determined individually for wild-type and db/db mice. The amount of NREM and REM sleep (minutes), as well as NREM EEG delta (1–4 Hz) power (NDP) was calculated as a percentage change from respective baseline levels. The recovery period was divided into time blocks corresponding to the last 4 h of the light phase, the 12-h dark period, and the total 16-h recovery period. The magnitude of sleep recovery (percentage change from baseline (%) ± SE) was compared between genotypes at each respective time block (

^*P < 0.05,

^†P < 0.01). Sleep recovery time is consistently reduced in magnitude in db/db vs. wt mice.