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. 2008 Oct 22;295(6):R2084–R2096. doi: 10.1152/ajpregu.90653.2008

Fig. 9.

Fig. 9.

Effect of L-733060 on relationship between IVP and tonic mean rectified EUS-EMG activity in intact phVCs (A), SCI phVCs (B), and SCI npVCs (C). The dips in several curves in A (arrows), most pronounced at ∼20–25 mmHg, are all from phase 1 of the micturition cycle, and occur because the only rat having opening pressures this high also exhibited very little EUS-EMG activity during phase 1 but had pronounced activity during phase 4. The anomalous portion of the 10 μg curve in B arises because, whereas 10 rats contribute data to the curves at 15 mmHg, only 1 rat (and only 1 contraction) contributed data to this high-pressure part of the curve. For the anomalous portion of the 100 μg curve in B, again only 1 rat contributed to data at 25 mmHg and above. With such anomalies accounted for, there appears to be little difference between the curves for intact phVCs, SCI phVCs, and SCI npVCs (other than the lower peak pressure for intact phVCs as per Fig. 6D), and there is no indication that L-733060 affects tonic EUS-EMG activity.