Table 1.
Preischemic left ventricular functional parameters of 3-mo-old offspring of prenatal saline control and cocaine treatments
| HR, beats/min | LVDP, mmHg | LVEDP, mmHg | dP/dtmax, mmHg/s | dP/dtmin, mmHg/s | CF, ml/min | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Male | ||||||||||||
| Control (n = 15) | 264±8 | 118±8 | 5±0 | 3,832±193 | 2,491±103 | 11±1 | ||||||
| Cocaine (n = 15) | 255±6 | 119±7 | 6±0 | 3,745±209 | 2,518±162 | 12±1 | ||||||
| TIP control (n = 10) | 265±9 | 120±5 | 6±0 | 3,789±212 | 2,459±120 | 11±1 | ||||||
| TIP cocaine (n = 10) | 272±8 | 116±9 | 5±0 | 3,822±225 | 2,386±154 | 11±1 | ||||||
| Female | ||||||||||||
| Control (n = 10) | 269±12 | 109±9 | 6±0 | 3,307±204 | 2,260±140 | 10±1 | ||||||
| Cocaine (n = 10) | 255±6 | 110±10 | 5±0 | 3,197±301 | 2,207±122 | 10±1 | ||||||
| TIP control (n = 10) | 255±10 | 107±10 | 5±0 | 3,241±474 | 2,014±280 | 10±1 | ||||||
| TIP cocaine (n = 10) | 261±14 | 104±11 | 5±0 | 3,184±258 | 2,195±185 | 10±1 | ||||||
Values are means ± SE; n, no. of animals. HR, heart rate; LVDP, left ventricular developed pressure; LVEDP, left ventricular end-diastolic pressure; dP/dtmax, maximal rate of contraction; dP/dtmin, maximal rate of relaxation; CF, coronary flow; TIP, PKCɛ translocation inhibitory peptide.