Fig. 4.

The effect of SAC reversal potential (E_SAC) on G_SAC-induced cell depolarization and automaticity in rat ventricular myocytes. A: at a relatively low value of G_SAC (2.4 nS), increasing E_SAC levels from −20 to 0 mV significantly increased the G_SAC-induced cell depolarization. The sustained automaticity was successfully induced by the G_SAC at E_SAC = 0 mV, but not at the E_SAC value of −10 or −20 mV. B: bar graph showing the cell depolarization induced by 2.4-nS G_SAC at the E_SAC level of −20, −10, and 0 mV (n = 6).