Fig. 8.

Myocardial Po₂ at the site of cell transplantation. Myocardial Po₂ values were measured using in vivo EPR oximetry. Myocardial Po₂ measured at the therapeutic site on day 0 and then at 4 wk after transplantation of MSCs. No MI was induced in the control group. Values are expressed as means ± SD (n = 4 animals/group). The MI group shows a significant recovery of Po₂ at 4 wk. At 4 wk, the recovery of Po₂ in the MI + MSC group was significantly higher than the MI group. The results indicate that treatment of MI in the ischemic heart by MSCs improved tissue oxygenation.