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. 2009 Mar 20;296(5):H1336–H1343. doi: 10.1152/ajpheart.01095.2008

Table 2.

Pathways detected by Ingenuity pathway analysis of genes significantly differentially expressed in the aortic wall of B6.apoE−/− and C3H.apoE−/− mice fed a chow or Western diet

Pathway Name Gene Symbol Gene Name Affymetrix ID Fold Change In Fold Change P Gene Product Location Gene Ontology Type
Chow diet
Calcium signaling ACTC1 Actin, α, cardiac muscle 1 1415927_at 25.992 0.000020 Cytoplasm Other
MEF2C Myocyte enhancer factor 2C 1421028_a_at 9.19 0.000101 Nucleus Transcription regulator
MYH6 Myosin, heavy chain 6, cardiac muscle, α (cardiomyopathy, hypertrophic 1) 1448554_s_at 157.586 0.000020 Cytoplasm Enzyme
MYL3 Myosin, light chain 3, alkali; ventricular, skeletal, slow 1427768_s_at 6.063 0.000618 Cytoplasm Other
MYL4 Myosin, light chain 4, alkali; atrial, embryonic 1422580_at 59.714 0.000052 Cytoplasm Other
MYL7 Myosin, light chain 7, regulatory 1449071_at 194.012 0.000020 Cytoplasm Enzyme
RCAN2 Regulator of calcineurin 2 1450243_a_at 12.126 0.000046 Unknown Other
RYR2 Ryanodine receptor 2 (cardiac) 1450123_at 9.849 0.000552 Plasma membrane Ion channel
TNNC1 Troponin C type 1 (slow) 1418370_at 8.574 0.000068 Cytoplasm Other
TNNI3 Troponin I type 3 (cardiac) 1422536_at 24.251 0.000020 Cytoplasm Transporter
TNNT2 Troponin T type 2 (cardiac) 1424967_x_at 181.019 0.000020 Cytoplasm Other
Butanoate metabolism ALDH1A1 Aldehyde dehydrogenase 1 family, member A1 1416468_at 9.19 0.002250 Cytoplasm Enzyme
HMGCS2 3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) 1423858_a_at 45.255 0.000030 Cytoplasm Enzyme
MYO5B Myosin VB 1452298_a_at −7.464 0.001486 Cytoplasm Enzyme
Acute phase response signaling HAMP Hepcidin antimicrobial peptide 1419197_x_at 19.698 0.000078 Extracellular space Other
IL6ST Interleukin 6 signal transducer (gp130, oncostatin M receptor) 1421239_at 12.996 0.000189 Plasma membrane Transmembrane receptor
RBP7 Retinol binding protein 7, cellular 1449461_at −36.758 0.000020 Cytoplasm Other
SOCS3 Suppressor of cytokine signaling 3 1455899_x_at 32 0.000618 Cytoplasm Other
TRF Transferrin 1425546_a_at −12.996 0.000030 Extracellular space Transporter
Nitric oxide signaling in the cardiovascular system GUCY1A3 Guanylate cyclase 1, soluble, α3 1420534_at 12.996 0.000020 Cytoplasm Enzyme
PLN Phospholamban 1460332_at 11.314 0.000130 Cytoplasm Other
RYR2 Ryanodine receptor 2 (cardiac) 1450123_at 9.849 0.000552 Plasma membrane Ion channel
Hepatic fibrosis COL1A2 Collagen, type I, α2 1423110_at 6.063 0.000020 Extracellular space Other
MYH6 Myosin, heavy chain 6, cardiac muscle, α (cardiomyopathy, hypertrophic 1) 1448554_s_at 157.586 0.000020 Cytoplasm Enzyme
MYL3 Myosin, light chain 3, alkali; ventricular, skeletal, slow 1427768_s_at 6.063 0.000618 Cytoplasm Other
MYL4 Myosin, light chain 4, alkali; atrial, embryonic 1422580_at 59.714 0.000052 Cytoplasm Other
MYL7 Myosin, light chain 7, regulatory 1449071_at 194.012 0.000020 Cytoplasm Enzyme
Western diet
Calcium signaling ACTC1 Actin, α, cardiac muscle 1 1415927_at 68.594 0.00002 Cytoplasm Other
ATP2A2 ATPase, Ca2+ transporting, cardiac muscle, slow twitch 2 1452363_a_at 3.732 0.00003 Cytoplasm Transporter
CASQ2 Calsequestrin 2 (cardiac muscle) 1422529_s_at 3.482 0.001486 Cytoplasm Other
CHRNA3 Cholinergic receptor, nicotinic, α3 1452010_at 16 0.000618 Plasma membrane Transmembrane receptor
MYH6 Myosin, heavy chain 6, cardiac muscle, α (cardiomyopathy, hypertrophic 1) 1448554_s_at 119.428 0.000023 Cytoplasm Enzyme
MYL4 Myosin, light chain 4, alkali; atrial, embryonic 1422580_at 16 0.00002 Cytoplasm Other
MYL7 Myosin, light chain 7, regulatory 1449071_at 128 0.00002 Cytoplasm Enzyme
NFATC2 Nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 2 1425901_at −8.574 0.00107700 Nucleus Transcription regulator
RYR2 Ryanodine receptor 2 (cardiac) 1450123_at 2.83 0.003355 Plasma membrane Ion channel
TNNC1 Troponin C type 1 (slow) 1418370_at 10.556 0.00013 Cytoplasm Other
TNNI3 Troponin I type 3 (cardiac) 1422536_at 137.187 0.00002 Cytoplasm Transporter
TNNT2 Troponin T type 2 (cardiac) 1424967_x_at 147.033 0.00002 Cytoplasm Other
Phenylalanine metabolism GOT1 Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 1450970_at 3.732 0.003355 Cytoplasm Enzyme
GOT2 Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) 1417716_at 4 0.001077 Cytoplasm Enzyme
PRDX2 Peroxiredoxin 2 1430979_a_at 11.314 0.00225 Cytoplasm Enzyme
Glutamate metabolism GOT1 Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 1450970_at 3.732 0.003355 Cytoplasm Enzyme
GOT2 Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) 1417716_at 4 0.001077 Cytoplasm Enzyme
GPT2 Glutamic pyruvate transaminase (alanine aminotransferase) 2 1455007_s_at −45.255 0.00003000 Unknown Enzyme
Arginine and proline metabolism CKMT2 Creatine kinase, mitochondrial 2 (sarcomeric) 1428722_at 13.929 0.000046 Cytoplasm Kinase
GAMT Guanidinoacetate N-methyltransferase 1422558_at −12.126 0.00249000 Cytoplasm Enzyme
GOT1 Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 1450970_at 3.732 0.003355 Cytoplasm Enzyme
GOT2 Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) 1417716_at 4 0.001077 Cytoplasm Enzyme
Alanine and aspartate metabolism GOT1 Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 1450970_at 3.732 0.003355 Cytoplasm Enzyme
GOT2 Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) 1417716_at 4 0.001077 Cytoplasm Enzyme
GPT2 Glutamic pyruvate transaminase (alanine aminotransferase) 2 1455007_s_at −45.255 0.00003000 Unknown Enzyme
GOT1 Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 1450970_at 3.732 0.003355 Cytoplasm Enzyme
GOT2 Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) 1417716_at 4 0.001077 Cytoplasm Enzyme
Parkinson's signaling MAPK14 Mitogen-activated protein kinase 14 1416704_at −6.063 0.00304100 Cytoplasm Kinase
SNCA Synuclein, α (non-A4 component of amyloid precursor) 1436853_a_at −6.964 0.00011400 Cytoplasm Other
Cysteine metabolism GOT1 Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 1450970_at 3.732 0.003355 Cytoplasm Enzyme
GOT2 Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) 1417716_at 4 0.001077 Cytoplasm Enzyme
HS3ST1 Heparan sulfate (glucosamine) 3-O-sulfotransferase 1 1423450_a_at −3.482 0.00016700 Cytoplasm Enzyme
BMP signaling pathway BMPR2 Bone morphogenetic protein receptor, type II (serine/threonine kinase) 1419616_at −17.148 0.00034600 Plasma membrane Kinase
EGFR Epidermal growth factor receptor [erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian] 1424932_at 7.464 0.003355 Plasma membrane Kinase
MAPK14 Mitogen-activated protein kinase 14 1416704_at −6.063 0.00304100 Cytoplasm Kinase
SMAD4 SMAD family member 4 1422485_at 3.249 0.00013 Nucleus Transcription regulator