Fig. 2.
PM2.5 exposure enhances aortic response to phenylephrine (PE) through activation of RhoA/Rho-kinase (ROCK). A and B: aortic rings were mounted in myograph chambers. After equilibration, responses to PE were analyzed. n = 6 animals/group. *P < 0.05 vs. the same exposure infused with vehicle; #P < 0.05 vs. FA infused with the same drug; $P < 0.05 vs. the same exposure infused with ANG II. C and D: aortic rings were precontracted by PE (10−7.5 M), and fasudil was then added in an accumulative manner. n = 6 animals/group. *P < 0.05 vs. the same exposure infused with vehicle; #P < 0.05 vs. FA infused with the same drug; $P < 0.05 vs. the same exposure infused with ANG II.