Fig. 6.
PM2.5 exposure increases the mRNA expression of guanine nucleotide exchange factors (GEFs) l-arginine (LARG; A), PDZ-RhoGEF (B), and p115RhoGEF (C). Results are fold increases over GAPDH. Total RNA was prepared from heart tissue, and the mRNA expression of the indicated genes was analyzed by real-time RT-PCR. n = 6 animals/group. *P < 0.05 vs. the same exposure in animals infused with vehicle; #P < 0.05 vs. FA exposure in animals infused with ANG II or fasudil; $P < 0.05 vs. the same exposure in animals infused with ANG II.