Table 2.

Cardiac ultrasound analyses: WT vs. IL-6^−/− mice

Age/Genotype	LVAWd, mm	LVAWs, mm	LVPWd, mm	LVPWs, mm	%FS	%EF
Day 5
WT	0.44±0.11	0.76±0.22	0.47±0.03	0.68±0.08	45.98±5.22	80.03±5.08
IL-6−/−	0.38±0.04	0.68±0.05	0.42±0.05	0.60±0.09	37.78±3.28*	71.01±4.56*
Day 15
WT	0.54±0.05	0.92±0.07	0.59±0.04	0.92±0.12	48.50±8.47	80.03±5.08
IL-6−/−	0.43±0.09*	0.70±0.11*†	0.54±0.04*	0.71±0.07†	31.50±5.81*†	61.15±7.93*†
Adult
WT	0.91±0.08	1.52±0.22	0.96±0.02	1.39±0.19	43.36±7.80	74.70±7.96
IL-6−/−	0.64±0.11*†	1.02±0.19*†	0.74±0.10*†	1.01±0.12*†	31.79±5.10*†	60.95±7.03*†

Values are means ± SD; N = 7–10 animals per condition. Echocardiographic analyses of IL-6^−/− vs. WT mice are shown: M-mode image analysis for neonatal day-5, day-15, and adult animals. LVAWd and LVAWs, left ventricular anterior walls during diastolic and systolic phases, respectively; LVPWd and LVPWs, left ventricular posterior walls during diastolic and systolic phases, respectively; FS, fractional shortening; EF, ejection franction.

^*P < 0.05,

^†P < 0.01, and

^*†P < 0.001 vs. WT.