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Model of PDE activity localized with the β2-adrenergic receptor (β2AR) and PGI2 receptor (IPR) in rabbit and human erythrocytes. Activation of the IPR leads to generation of cAMP in a restricted cAMP pool that is hydrolyzed by PDE3. In contrast, activation of the β2AR leads to generation of a distinct cAMP pool that is regulated by the activities of both PDE2 and PDE4. AC, adenylyl cyclase; Gs, heterotrimeric G protein.
