Table 2.

Vascular effects of air or CS exposure in WT and GSTP-null mice

	WT Mice		GSTP-Null Mice
	Air	CS	Air	CS
PE
Tension, mg	1256±196	1112±119	875±203	1246±214
Tension, g/mg wet wt	1.16±0.19	0.88±0.13	0.57±0.13	1.07±0.21
Tension, PE/80 mM K+ buffer	106±3	93±10	107±4	102±12
EC50, nM	68±17	94±19	83±24	107±33
pD2	7.18±1.61	7.07±0.12	7.11±1.59	7.01±1.57
ACh
Relaxation, %PE	−61±8	−73±10	−80±9	−48±9†
EC50, nM	328±115	665±454	132±54	251±131
pD2	6.55±1.47	6.52±0.32	6.71±1.52	6.76±1.52
GTN
Relaxation, %PE*	−114±17	ND	−103±4	ND
EC50, nM*	27±7	ND	83±67	ND
pD2*	7.63±0.10	ND	7.60±0.32	ND
SNP
Relaxation, %PE	−110±8	−105±17	−158±20	−100±6†
EC50, nM*	38±21	ND	9±3	ND
pD2*	7.68±0.19	ND	8.12±0.13	ND

Values are means ± SE; n = 4 mice/group. Male 12- to 14-wk-old WT or GSTP-null mice were exposed to air or CS (5 h/day) for 3 days. Mice were euthanized 24 h after exposure after an 8-h fast. PE, phenylephrine; GTN, glyceryl trinitrate; SNP, sodium nitroprusside; ND, not determined.

^*Data from naïve mice only (n = 4 mice/group).

^†P< 0.05 vs. the matched air-exposed control group.