Table 3.

Expression of antioxidant enzymes in the lung and liver after 3-day air or CS exposure in male WT and GSTP-null mice

	FR-1	ALDH3A1	GSTP	CYP1A1/1A2	CYP2E1	CYP2B1	NQO1
Lung
WT mice
Air	1.00±0.03	1.00±0.01	1.00±0.05	-	-	-	1.00±0.01
CS	1.22±0.03*	1.08±0.05	0.92±0.05	-	-	-	1.11±0.05
GSTP-null mice
Air	1.01±0.02	1.10±0.06	Null	-	-	-	1.00±0.02
CS	0.87±0.03*	1.04±0.02	Null	-	-	-	0.83±0.05
Liver
WT mice
Air	-	-	-	1.00±0.08	1.00±0.03	1.00±0.05	1.00±0.16
CS	-	-	-	1.38±0.09*	1.07±0.09	1.06±0.04	0.85±0.07
GSTP-null mice
Air	-	-	-	1.74±0.05*	1.28±0.14	1.19±0.08	1.14±0.07
CS	-	-	-	1.64±0.52	1.16±0.07	1.32±0.05	0.91±0.01*

Values are means ± SE; n = 3 mice/group. Western blot band intensity was normalized to total lane amido black staining. Relative protein expression was calculated as a percentage of the WT air-exposed value. FR-1, FGF-regulated protein 1; ALDH3A1, aldehyde dehydrogenase 3A1; CYP, cytochrome P-450; NQO1, NAD(P)H:quinone oxidoreductase 1.

^*P < 0.05 vs. the WT air-exposed group.