Table 5.

Blood parameters in WT and GSTP-null mice exposed to air or acrolein

	WT Mice		GSTP-Null Mice
	Air	Acrolein	Air	Acrolein
Hct, %	45.0±0.5	46.0±1.0	41.3±0.8	44.7±0.5
Buffy coat, %	0.9±0.0	1.7±0.0*	1.5±0.1	1.4±0.1
Cholesterol, mg/dl	94±2	95±3	113±3	112±2
HDL, mg/dl	68±3	64±2	75±3	77±2
LDL, mg/dl	14±1	16±1	15±1	13±1
Triglycerides, mg/dl	76±8	72±5	76±7	56±4*
TP, g/l	4.78±0.08	4.83±0.11	4.73±0.08	4.70±0.13
Albumin, g/l	2.96±0.03	3.04±0.02	2.88±0.07	3.04±0.08
LDH, U/l	140±12	160±1	205±17	235±24
CK, U/l	209±28	275±26	157±12	156±13
ALT, U/l	28±1	28±1	34±2	31±2
AST, U/l	59±6	69±4	64±4	66±5

Values are means ± SE; n = 4 WT mice/group and 8 GSTP-null mice/group. Male 12- to 14-wk-old WT or GSTP-null mice were exposed to air or acrolein (1 ppm, 5 h/day) for 3 days. Mice were euthanized 16 h after exposure.

^*P < 0.05 vs. the matched air-exposed control group.