Fig. 3.

Release of thromboinflammatory factors by EPCs. The release of the thromboinflammatory factors myeloperoxidase (MPO, A), tissue factor (B), and plasminogen activator inhibitor-1 (PAI-1, C) by early EPCs (n = 4), adult blood late EPCs (n = 3), and cord blood late EPCs (n = 4) is shown over a 24-h period. The data for each factor are presented as means ± SE of secreted ng/million adherent cells. In A, the overall P value for comparative MPO release by ANOVA was *P < 0.005, and post hoc analysis revealed that early EPCs had markedly higher MPO release (**P < 0.01) compared with either adult or cord blood late EPCs, both of which showed only minimal MPO release. The release of tissue factor (B) was also markedly higher in early EPCs (*P < 0.05 vs. either of the two late EPC groups), whereas there was no significant difference in tissue factor release between the two late EPC groups. In C, the release of PAI-1 is shown, and statistical analysis demonstrated that adult late EPCs had significantly higher PAI-1 release (P < 0.05) than early EPCs and a trend toward higher PAI-1 release compared with cord blood late EPCs.