Fig. 6.

Secretion of the proinflammatory chemokine by EPCs treated with simvastatin. Adult blood-derived late EPCs were cultured with increasing doses of simvastatin to assess its effect on the release of MCP-1. Released MCP-1 was assessed by enzyme-linked immunosorbent assay and normalized by cell number. Data are means ± SE of secreted MCP-1 in ng/million cells. Cells showed a significant decreases in their release of MCP-1 per repeated-measures ANOVA, n = 4 with simvastatin treatment. Post hoc analysis showed that 1 μM simvastatin markedly reduced MCP-1 release (**P < 0.01 vs. control).