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. 2009 Mar 6;296(5):H1577–H1585. doi: 10.1152/ajpheart.01255.2008

Fig. 4.

Fig. 4.

The effect of chronic intracerebroventricular infusions of an estrogen receptor antagonist on Aldo/NaCl-induced hypertension in female rats. Daily MAP (A) and HR (C) before and during systemic infusions of Aldo and access to 1% NaCl in peripheral ICI or intracerebroventricular ICI-treated female rats are shown. B and D: average changes in MAP and HR induced by Aldo infusion in all groups. Control (C) days (C1, C3, and C5) are followed by 28 days of peripheral or central ICI and systemic Aldo infusion. *P < 0.05 compared with baseline; #P < 0.05 compared with females given peripheral ICI.