Fig. 1.

Effects of doxorubicin (DOX) with or without peroxynitrite scavengers (PSs) on myocardial inducible nitric oxide (NO) synthase (iNOS) expression in vivo. A: DOX-induced increased myocardial iNOS mRNA (left) and protein (right) levels, which were not affected by PSs. *P < 0.05 vs. vehicle; #P < 0.05 vs. DOX. n = 6 per group for protein samples and n = 9 per group for mRNA samples. B: immunohistochemistry demonstrated widespread DOX-induced increased myocardial iNOS expression. FeTMPyP, iron α,β,γ,δ-tetrakis(4-N-methylpyridyl)porphine; MnTMPyP, mangenese α,β,γ,δ-tetrakis(4-N-methylpyridyl)porphine.