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. 2009 Mar 13;296(5):H1466–H1483. doi: 10.1152/ajpheart.00795.2008

Fig. 2.

Fig. 2.

Effects of DOX with or without PSs on myocardial superoxide/ROS formation, its sources, and antioxidant enzyme activities in vivo. A: effects of PSs on DOX-induced superoxide/ROS formation from frozen heart sections using dihydroethidium (DHE). *P < 0.05 vs. vehicle; #P < 0.05 vs. DOX. n = 6 per group. B: effects of PSs on DOX-induced myocardial xanthine oxidase mRNA (left) and protein (right) expression. A representative blot from 3 sets of experiments is shown. The blot was also probed for β-actin as a loading control. *P < 0.05 vs. vehicle; #P < 0.05 vs. DOX. n = 6 per group. C: effects of DOX with or without PSs on mitochondrial superoxide/ROS generation in isolated mitochondria. *P < 0.05 vs. vehicle; #P < 0.05 vs. DOX. n = 6 per group. D: effects of DOX with or without PSs on myocardial SOD activity. n = 6 per group. E and F: effects of DOX with or without PSs on myocardial catalase (E) and glutathione peroxidase (F) activities. *P < 0.05 vs. vehicle; #P < 0.05 vs. DOX. n = 6 per group.