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. 2009 Mar 13;296(5):H1466–H1483. doi: 10.1152/ajpheart.00795.2008

Fig. 3.

Fig. 3.

Effects of DOX with or without PSs on myocardial nitrotyrosine (NT) formation, matrix metalloproteinase (MMP)-2 and MMP-9 gene expression, and poly(ADP-ribose) polymerase (PARP) and myeloperoxidase (MPO) activities in vivo. A: effects of PSs on DOX-induced NT formation from heart tissue homogenates. B: effects of PSs on DOX-induced myocardial MMP-2 and MMP-9 mRNA expression. *P < 0.05 vs. vehicle; #P < 0.05 vs. DOX. n = 9 per group. C: effects of PSs on DOX-induced myocardial PARP activity. *P < 0.05 vs. vehicle; #P < 0.05 vs. DOX. n = 6 per group. D: effects of DOX with or without PSs on myocardial MPO staining. A representative sample from liver ischemia-reperfusion (I/R) injury with marked neutrophil infiltration as previously described (4, 52) and stained under the same conditions was used as a positive control.