Table 4.

Comparison of the prediction performance obtained by using ESA- and HOA-normalized target ASA values.

Res.	Freq	MAE				CC				P-values
		Rel (ESA) (%)	Rel (HOA) (%)	Abs (ESA) (Å2)	Abs (HOA) (Å2)	Rel (ESA)	Rel (HOA)	Abs (ESA)	Abs (HOA)	t-test	u-test
A	30972	14.81	14.13	16.22	15.64	0.63	0.65	0.63	0.66	0.002	5.0e-10
C	5156	10.39	13.28	14.53	12.25	0.33	0.35	0.33	0.37	8.39e-13	0
D	22482	21.04	17.30	30.31	29.73	0.49	0.50	0.49	0.52	0.018	0.579
E	25303	20.09	17.00	35.11	34.12	0.49	0.50	0.49	0.52	5.21e-04	0.027
F	15016	11.60	11.63	23.22	21.71	0.40	0.44	0.40	0.45	7.28e-06	0
G	27935	20.25	17.60	15.31	15.90	0.51	0.52	0.50	0.54	0.621	2.3e-4
H	8596	16.22	16.36	29.50	29.28	0.54	0.55	0.54	0.56	0.825	0.581
I	21345	10.80	11.21	20.05	17.55	0.46	0.50	0.46	0.50	2.79e-13	0
K	21997	17.82	17.46	36.64	36.97	0.43	0.43	0.43	0.45	0.015	0.008
L	34119	11.40	11.27	20.86	19.34	0.47	0.51	0.47	0.51	1.58e-12	0
M	8130	12.20	12.99	24.40	21.84	0.48	0.52	0.48	0.53	3.44e-10	0
N	16660	20.87	17.63	30.55	30.38	0.53	0.52	0.53	0.54	0.621	0.148
P	17214	17.96	18.39	25.47	25.23	0.52	0.53	0.52	0.54	0.514	0.426
Q	14334	18.73	17.21	33.46	33.31	0.52	0.52	0.52	0.53	0.993	0.194
R	18302	17.57	16.21	40.23	39.85	0.46	0.46	0.46	0.47	0.243	0.647
S	22408	18.62	16.48	21.83	21.64	0.56	0.57	0.56	0.58	0.944	0.092
T	20973	16.71	15.61	23.17	22.97	0.56	0.58	0.56	0.58	0.710	0.343
V	26399	11.72	11.69	18.04	16.56	0.52	0.55	0.51	0.55	0.000	0
W	5625	11.77	13.80	28.35	26.76	0.36	0.37	0.36	0.38	0.008	9.93e-7
Y	13636	13.24	13.45	28.29	27.73	0.42	0.43	0.42	0.43	0.110	0.040

Abbreviations: Res: Residue ID, MAE: mean absolute error in prediction measured in percentage points, CC: Correlation coefficient, Rel: relative ASA values, Abs: using absolute area units, t-test: Student's t-test statistics, u-test: Mann-Whitney u-test