Table 3.
Summary estimates of effect of non-invasive ventilation in critically ill adults
| Outcome | No studies (No of patients) | Summary estimate (95% CI) | P value (summary estimate) | P value (heterogeneity) | I2 (%) |
|---|---|---|---|---|---|
| Mortality | 12 (530) | 0.55* (0.38 to 0.79) | 0.001 | 0.49 | 0 |
| VAP | 11 (509) | 0.29* (0.19 to 0.45) | <0.001 | 0.51 | 0 |
| Weaning failures | 4 (141) | 0.72* (0.37 to 1.42) | 0.34 | 0.35 | 9.2 |
| Length of stay: | |||||
| Intensive care | 10 (485) | −6.27† (−8.77 to −3.78) | <0.001 | <0.001 | 77.4 |
| Hospital | 8 (401) | −7.19† (−10.80 to −3.58) | <0.001 | <0.001 | 76.8 |
| Duration of mechanical ventilation: | |||||
| Total | 7 (385) | −5.64† (−9.50 to −1.77) | 0.004 | <0.001 | 85.6 |
| Related to weaning | 6 (224) | −0.94† (−3.24 to 1.36) | 0.42 | <0.001 | 91.8 |
| Endotracheal‡ | 9 (391) | −7.81† (−11.31 to −4.31) | <0.001 | <0.001 | 89.9 |
| Adverse events: | |||||
| Reintubation | 6 (328) | 0.73* (0.40 to 1.34) | 0.31 | 0.19 | 32.4 |
| Tracheostomy | 3 (141) | 0.16* (0.04 to 0.75) | 0.02 | 0.30 | 17.2 |
| Arrhythmia | 2 (63) | 1.05* (0.17 to 6.67) | 0.96 | 0.35 | 0 |
VAP=ventilator associated pneumonia.
*Relative risk.
†Weighted mean difference.
‡Invasive ventilation.