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. 2009 Jun;11(6):509–517. doi: 10.1593/neo.81578

Figure 3.

Figure 3

NK cells are required for ADCC activity in vitro. The ADCC activity of 3F2-3M was evaluated in purified NK and non-NK cells isolated from healthy donors as described in Materials and Methods. Potent and reproducible ADCC activity against MDA-MB-231 cells (A) and A549 NSCLC cells (B) in the presence of human purified NK cells but not purified NK-depleted PBMCs. Error bars, SEM. Antibody concentrations tested were 5 ng/ml (diamonds), 50 ng/ml (hatched lines), and 500 ng/ml (solid bars) at an effector-to-target ratio of 10:1 for the MDA-MB-231 study and 5:1 for the A549 study. Data are representative of two independent experiments.