Table 2.

Toxic effects reported as possibly, probably or definitely related to treatment

Toxicity (n = 54)	Grade 1		Grade 2		Grade 3		Grade 4
	n	%	n	%	n	%	n	%
Neutropenia	4	7	8	15	8	15	11	20
Anemia	12	22	17	31	8	15	1	2
Thrombocytopenia	6	11	6	11	13	24	1	2
Hypotension	1	2	3	6	2	4	0	0
Thromboembolism	0	0	0	0	1	2	0	0
Skin rash	12	22	17	31	11	20	0	0
Diarrhea	18	33	8	15	14	26	1	2
Dehydration	0	0	6	11	11	20	0	0
Febrile neutropenia	0	0	0	0	4	7	0	0
Documented infection	0	0	0	0	6	11	0	0
Dyspnea	0	0	11	20	4	7	0	0
Elevated serum creatinine	13	24	14	26	2	4	0	0
Auditory loss	0	0	3	6	3	6	0	0
Edema	4	7	1	2	1	2	0	0
Fatigue (asthenia, lethargy, malaise)	10	19	26	48	11	20	2	4
Emesis	9	17	13	24	13	24	1	2
Mucositis/stomatitis	7	13	2	4	4	7	0	0
Melena/Gastrointestinal bleeding	0	0	0	0	1	2	0	0
Hematuria	2	4	1	2	1	2	0	0
Elevated ALT	7	13	2	4	1	2	0	0
Elevated alkaline phosphatase	6	11	0	0	1	2	0	0
Hypokalemia	13	24	0	0	5	9	2	4
Hypomagnesemia	6	11	12	22	3	6	3	6
Hyponatremia	14	26	0	0	4	7	0	0
Neuropathy: motor	12	22	5	9	2	4	0	0
Neuropathy: sensory	9	17	2	4	1	2	0	0
Hypocalcemia	6	11	9	17	2	4	1	2

ALT, alanine aminotransferase.