Skip to main content
. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: J Immunol. 2009 Jun 1;182(11):6670–6681. doi: 10.4049/jimmunol.0803683

Figure 10.

Figure 10

Enhanced immunogenicity of full length HBcAg183 is mediated by TLR-7 signaling. (A). Groups of 3 wild-type B10/+/+ or B10/TLR-7KO mice were immunized i.p. with 10 μg in saline of either full length HBcAg183 (ssRNA+) or HBcAg149 (ssRNA−). At 1, 2, 4 and 6 weeks after immunization IgG anti-HBc antibodies in pooled sera were measured by ELISA. (B). Groups of 3 wild-type B10/+/+ mice or B10/TLR-7KO mice were immunized i.p. with 10 μg in saline of full length HBcAg183 (ssRNA+). Two weeks after immunization anti-HBc antibodies of the indicated IgG isotypes were measured in pooled sera by ELISA. The results depicted represent mean values (± SD) of experiments performed using pooled serum samples on 2 separate occasions (*P = 0.05, **P = 0.005).