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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: J Immunol. 2009 Jun 1;182(11):6670–6681. doi: 10.4049/jimmunol.0803683

Figure 13.

Figure 13

TLR-7 signaling occurs in B cells. Two groups of 6 B10/BKO mice served as recipients for the adoptive transfer of 30 × 106 fractionated splenic B cells derived from either B10/+/+ mice or B10/TLR-7KO mice. Successful B cell grafting was confirmed by the presence of serum IgG 3 days after adoptive transfer. At 7 days after adoptive transfer mice were immunized i.p. with HBcAg183 (ssRNA+) (20 μg in saline) and boosted with 10 μg of HBcAg183 in saline. Sera was collected, pooled and assayed for IgM anti-HBc antibodies at the indicated time points by ELISA.