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The HBcAg protein is not a TLR ligand. Four HBc/HBeAg preparations were screened for TLR ligand activity on a panel of human TLR expressing HEK293 cells. TLR ligand activity was determined by NF-Kβ activation as described in Methods and Materials. The 2 full length HBcAg183 preparations contained no endotoxin, the HBeAg preparation contained low level endotoxin (1.0 ng/ml) and the truncated HBcAg149 preparation was contaminated with 10 ng/ml of endotoxin.
