Table 5.

Brief Summary of Previous Linkage Studies for Bone Phenotypes at the Loci Detected in This Study

Current results for aBMD-ABS			Previous linkage evidence
Region	LODE*	Sites	Phenotypes	LOD or p values	References
20q11	3.11	FN	FN vBMD in mice	LOD = 3.14	(40)
			Peak whole body aBMD in mice	p < 0.0020	(43)
			UD ABS	LOD = 2.24	(52)
			Whole body vBMD in mice	LOD = 6.6	(61)
Xp11	2.46	FN	Hip aBMD	LOD = 2.15	(34)
			Cross-sectional area at FN	LOD = 2.23	(53)
			Cortical thickness at FN	LOD = 2.38
			Cortical thickness at FN	LOD = 3.45	(62)
Xq27	4.30	LS	UD aBMD	LOD = 2.78	(16)
	2.43	UD	UD aBMD	LOD = 4.30	(34)
			Hip aBMD	LOD = 2.57
17q21	2.44	LS	LS aBMD in mice	p < 0.0001	(42)
			Femur head width	LOD = 3.6	(44)
			Peak bone mass in mice	LOD = 10.8	(63)
5q23	3.01	UD	UD aBMD	LOD = 3.39	(16)
			UD aBMD in females	LOD = 2.82
7p15	2.92	UD	Hip ABS	LOD = 2.53	(52)
			Cortical thickness at FN in females	LOD = 1.86	(53)
			LS aBMD	LOD = 2.15	(64)

* LOD_E indicates the equivalent LOD scores comparable to traditional univariate ones.

FN, femoral neck; LS, lumbar spine; UD, ultradistal forearm; aBMD, areal BMD; vBMD, volumetric BMD.