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. 2008 Sep 1;64(5-3):438–442. doi: 10.1016/j.biopsych.2008.03.028

Table 2.

Association Between Single SNP and Disease Status in Phase I, Combined Phase I and Phase II, and Familial Cases Using HRR Analysis

Bipolar Spectrum Disorder
 Psychotic Disorder
Phase I (62 Families) Phase I + II (154 Families) Familial Casesa (99 Families) Phase I (57 Families) Phase I + II (144 Families) Familial Casesa (102 Families)
DAOA
 rs3916966 .696 .966 .906 .843 .839 .616
 rs2391191 .889 .913 .735 .87 .891 .349
 rs2153674 .072 .353 .095 .066 .700 .233
 rs701567 .670 .593 .407 .278 .133 .031
 rs778326 .025 .111 .024 .010 .186 .018
 rs954580 .040 .107 .052 .049 .565 .252
COMT
 rs4680 .085 .046 .020 .340 .072 .149
 rs165599 .003 .829 .035 .015 .396 .103

COMT, catechol-O-methyl transferase; DAOA, d-amino acid oxidase activator; HRR, haplotype relative risk; SNP, single nucleoide polymorphism.

a

Familial cases include only families that contain at least two affected individuals.