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. Author manuscript; available in PMC: 2009 May 22.
Published in final edited form as: J Mol Med (Berl). 2008 Jul 4;86(10):1139–1152. doi: 10.1007/s00109-008-0374-7

Fig. 4.

Fig. 4

Monocyte-derived DCs of APECED patients produce low amounts of cytokines. MoDCs differentiated from APECED patients or control individuals were stimulated with LPS (100 ng/ml), C. albicans (MOI 1), or infected with Sendai virus (MOI 5) and cell culture supernatants were collected at 24 h after microbial stimulation and cytokine levels were determined by flow cytometric device using Human Th1/Th2 10plex Kit II containing a panel of ten cytokines. The data for TNF-α, IL-1β, IL-6, CXCL8, IL-10, and IL-12 levels in control individuals (n=6, white bars) and APECED patients (n=2–6, gray bars) are presented. The levels of other cytokines tested, IL-2, IL-4, IL-5, and IFN-γ remained undetectable. The statistical significances between the groups were calculated using Students t-test (*p<0.05)