Table 3.
Modification of hepatic gene expression in apoE-deficient mice following the consumption of Western diets enriched in LA isomers
| LA | c9, t11-CLA | t10, c12-CLA | SL2R t/cis | |||||
|---|---|---|---|---|---|---|---|---|
| n | 10 | 10 | 9 | |||||
| Genes Upregulated | ||||||||
| Sept4 | 1±0.5a | 0.9±0.4a | 1.5±0.6a | 0.7 | ||||
| Ly6d | 1.4±1.0b | 1.7±1.0b | 6.3±2.3a | 1.9 | ||||
| Fsp27 | 1.1±0.4b | 0.4±0.2c | 17±9a | 5.4 | ||||
| Pqlc3 | 1±0.4a | 0.8±0.6a | 1.3±0.3b | 0.7 | ||||
| Aqp4 | 1.1±0.6b | 0.2±0.2c | 1.8±1.1a | 3.2 | ||||
| Sdcbp | 1.1±0.6a | 0.6±0.4a | 1.4±0.4b | 1.2 | ||||
| Col1a1 | 1.1±0.6a | 1.1±0.9a | 7.2±6b | 2.7 | ||||
| Uck1 | 1.1±0.5a | 0.7±0.5a | 2.3±1.2b | 1.7 | ||||
| Vnn1 | 1.0±0.4a | 0.2±0.1b | 0.9±0.4a | 2.1 | ||||
| Cln6 | 1±0.4a | 0.8±0.2a | 1.5±0.7b | 0.9 | ||||
| Genes Downregulated | ||||||||
| Hsd3b5 | 1.1±0.4b | 1.8±1.3b | 0.01±0.01a | −7.5 | ||||
| Syt1 | 1.2±0.7a | 1.1±0.4a | 0.5±0.2b | −1.1 | ||||
| Tff3 | 3.4±3b | 12.5±4a | 0.9±0.5c | −3.8 | ||||
| Cyp7b1 | 0.5±0.2b | 2.3±1.2a | 0.3±0.1c | −2.9 | ||||
Values are the means ± SD in arbitrary units normalized to the cyclophilin B (Ppib) expression for each condition with the qRT-PCR. Means in the same row without a common letter differ significantly (P ≤ 0.05; Mann-Whitney U-test).