Skip to main content
. 2009 Mar 3;37(3):187–198. doi: 10.1152/physiolgenomics.90339.2008

Table 3.

Modification of hepatic gene expression in apoE-deficient mice following the consumption of Western diets enriched in LA isomers

LA c9, t11-CLA t10, c12-CLA SL2R t/cis
n 10 10 9
Genes Upregulated
Sept4 1±0.5a 0.9±0.4a 1.5±0.6a 0.7
Ly6d 1.4±1.0b 1.7±1.0b 6.3±2.3a 1.9
Fsp27 1.1±0.4b 0.4±0.2c 17±9a 5.4
Pqlc3 1±0.4a 0.8±0.6a 1.3±0.3b 0.7
Aqp4 1.1±0.6b 0.2±0.2c 1.8±1.1a 3.2
Sdcbp 1.1±0.6a 0.6±0.4a 1.4±0.4b 1.2
Col1a1 1.1±0.6a 1.1±0.9a 7.2±6b 2.7
Uck1 1.1±0.5a 0.7±0.5a 2.3±1.2b 1.7
Vnn1 1.0±0.4a 0.2±0.1b 0.9±0.4a 2.1
Cln6 1±0.4a 0.8±0.2a 1.5±0.7b 0.9
Genes Downregulated
Hsd3b5 1.1±0.4b 1.8±1.3b 0.01±0.01a −7.5
Syt1 1.2±0.7a 1.1±0.4a 0.5±0.2b −1.1
Tff3 3.4±3b 12.5±4a 0.9±0.5c −3.8
Cyp7b1 0.5±0.2b 2.3±1.2a 0.3±0.1c −2.9

Values are the means ± SD in arbitrary units normalized to the cyclophilin B (Ppib) expression for each condition with the qRT-PCR. Means in the same row without a common letter differ significantly (P ≤ 0.05; Mann-Whitney U-test).